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The Immune System,

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I need help this exam. It is immunology class. Here are the text books;The text book and Novel are these;?Text?: The Immune System, Peter Parham, 3rd Edition, Garland Publishing, 2009.;Novel?: The Compatibility Gene-How our bodies fight disease, attract others, and;define ourselves, Daniel M. Davis, Oxford Press, 2014.;Attachment Preview;Exam 2 imunology.docx Download Attachment;Matchthesegiantswiththeir"compatibility"contributions.OneGiantpercontribution.;Question 1 options;Pairwhoperformedmiceexperimentsonmate 1.;selectionandcompatibilitygenes.;2.;Neurologistwhoconnectedtheimmunesystem;withtherejectionofpregnancybyexaminingpre;3.;eclampsiaandfindingNKcellsandHLA;connections.;4.;A"submarine"epiphanyleadtoanunderstanding;5.;ofhowNKcellsdetectdiseasedcells.;missingself"hypothesis.;6.;Our"novel"author!;7.;synapse".;Eric Schadt;Ronald Herbman and;Rolf Kiessling;Klas Karre;Claus;Wedekind;Lewis Thomas;Jeanette and Ted;Boyse;KunioYamazaki;Examinedsimething"interesting"thatwasoften8. HubelandWiesel;foundinexperimentsandexplainedas;9. CarlaSchatz;Backgroundtheirexperimentsleadtothe;discoveryofNKcells.;10. Avi Kupfer;Computercodewriterforgeneticanalysisnew 11. Daniel Davis;approachtogenesandmedicalresearch.;Ashley;12.;Moffett;PerformedthesmellyTshirtexperimentto;examineifthroughscent,compatibilitygenescan;beidentifiedandinfluencematechoice.;ImmunoNeuropioneer,foundimmuneproteinsin;thebrain.;WontheNobelPrizeworkinvision,buttheirclaim;tofameinthisbookisbytrainingCarlaSchatz.;WorkedwiththeBoysesanddesignedtheYmaze;forthemousescentexperiment.;FollowedonCarlaSchats'workandworkedwith;hiswifeHannah.Theyusedmicroscopyand;watchedimmunecellsinteractwithothercellsto;forman"immunesynapse".;Livesofcellsaskedifdogscansniffouthuman;compatibilitygenes.;Match the terms from chapters 9 and 10 with the best description. Only one description per;match.;Question 2 options;MHCclassImoleculesexpressedinresponseto;1.;cellularstresstargetedbyTcellsandNKcells.;2.;MicrofoldcellsGutassociated"lympoidtissue;providesentrancetoPeyersPatch.;3.;CD40;NucleotidebindingOligoDomain,theseTLRlike;proteinsfunctionintheinnateimmunesystemto;4.;detectbacteriaingutepithelium.;Germinal;Center;CR1;BCellCo;Receptor;5.;Thesethreepeptidechaingsrunctiontorecognize IgM;andbindC3d.;6. IgE;Areaoflymphoidfolliclewherecentrocyte;proliferationoccurs.;7.;Waldeyer's;Ring;Highlyeffectiveandmostflexibleantibodyisotype;8. MCells;produced4subclassesfunctioninourimmune;system.;9. DimericIgA;Theligand(onTcells)andreceptor(onBcells);10.;allowscentrocytestosurviveanddividetoform;antibodyproducingplasmacells.;11.;KillerCellImmunoglobulinlikeReceptorInhibitory;recpetorforNKcellsthatdetectschangesinMHC;12.;1.;NodProteins;MICStress;Receptor;KIRReceptors;Antibodyisotypewithkeyroleinmucosaltissue;protection.;Firstantibodyisotypeproducedfunctionsmostlyas;apentamerbutcanalsoasamonomer.;Ringoflympoidtissues,includedthetonsilsand;adenoids.;BcellreceptorthatbindsC3b,allowsforC3b;cleavageandthenewlyformedC3disnowexposed;andcanbindtotheCR2Bcellcoreceptor.;Match.;Question 3 options;Liveattenuatedvirusvaccine,examplesarefor;Measles,MumpsandPolio.;Tighest"antibodyreceptorbinding.Cross;linkingcausesmastcelldegranulation.;Deathlydiseaseproducedbyvariola,produces;redspotsthatdevelopintopustulesandcanlead;todeath.;Poliovaccinefromkilledorinactivevirus.Also;approachusedforFluandRabies.;Whensmallmoleculesbindcovalentlytocell;surfaceantigensthiscanleadtomodifiedand;now"foreign"antigens.Anexamplewouldbe;allergiestodrugssuchaspenicillin.;Asolubleantigenleadstomastcell;degranulation.Anexamplewouldbeallergic;rhinitisorasthma.;Asolubleantigenleadstocomplementand;phagocytosis.Serumsicknesswouldbean;example.;Immuneresponse"helper"usedtoenhancethe;responsewhengeneratingantibodies.Freund's;completecontainingkilledmycobacteria,mineral;oilandantigensisanexample.;Causedbytheproductsofantigenspecific;effectorTcells.Macrophageactivationcanresult;incontactdermatitis,whileeosinophilactivation;canresultinchronicasthma.;OriginhasLatinnameforpustuleanddisease;nownameforsmallpoxvirusordisease.;Match.;Question 4 options;Immunosupression drugs that inhibit T cell activation;1.;Alloantigens;2.;Meansforhowtumorcellscanevadean;immunologicalresponse.AllowedifMICisclipped;3.;bycancercell.;GVHD;Panel Reactive Antibody--the higher the value the more 4.;difficult to find a donor;PRA;AmonoclonalantibodyusedtotreatnonHodgkins;lymphoma.;Hyperacute rejection;5.;Cyclosporin A and;tacrolimus;6.;Myeloablative;Subset of tumor associated antigens (named for;Cancer/Testis) that are not expressed in normal somatic;7.;cells.;Minor;Histocompatibility;Antigens;Amonoloclonolantibodyusedtotreatcolon;cancer.Recognizestheanticarcenoembryonic;antigen.;8.;Haploidentical;9.;CT antigens;Peptides(HYAntigens)thathaveallogenic;difference,NotMHC;10. NKG2KMIC;11. Heat Shock proteins;Transplanted organs are rejected du to antibodies against;ABO or HLA;12. AntiCEA;Akeyandclassicturmorspuressorprotein.;13. AntiCD20;Specificallythisproteinhasaroleindetectingcells;withDNAdamageandtargetingthemfor;Tumor Suppressor;14.;destructionviaApoptosis.;Genes;canalsoleadtothesupportofcancerdevelopment.;15. P53;Regular cellular job is to help keep proteins folded, but;for chapter 16, these proteins are used as a natural;adjuvant to produce anti-tumor "vaccines".;Conditioning regimine for bone marrow transplant that;will destroy the patients own bone marrow.;These genes encode proteins that prevent cell division;when cells have mutated.;genes can lead to the support of cancer development.;Graftversushostdiseasecanresultfrombone;marrowtransplantsthatattachthehost.;MHCcomplexantigensthesevarybetween;membersofthesamespecies;Relateddonorswith50%matchinHLAisotypes.;Question5(2.5points);Waldeyers ring includes which of the following? (Select all that apply.);Question5options;Peyers patches;lingualtonsils;adenoids;mesentericlymphnodes;palatinetonsils;1,2and3arecorrect;2,3and5arecorrect;Question6(2.5points);WhichofthefollowingdescribeMcellsinthegut?(Selectallthatapply.);Question6options;Theyderivetheirnamefrommucuscells.;TheyarelocatedinthedomeofaPeyerspatch.;They deliver antigens and pathogens from the lymphoid tissue to the luminal side of the gut mucosa;by transcytosis.;They are protected from digestive enzymes by a thick glycocalyx and a layer of mucus.;Theydonotdirectlyparticipateinantigenprocessingorpresentation.;2and5arecorrect;Allanswersarecorrect;Question7(2.5points);Thisvascularaddressinisfoundonendothelialcellsofintestinalmucosathatbindstointegrins;ofguthomingeffectorlymphocytes.;Question7options;CCL25;C-cadherin;NOD1;MAdCAM-1;Question8(2.5points);LigandbindingofNOD2resultsintheactivationofthe_____signalingpathwayandthe;productionofdefensins,chemokines,andcytokines.;Question8options;NFB;NKG2D;Toll-like receptor;CD94:NKG2A;Question9(2.5points);WhichofthefollowingcharacterizeMICAandMICBproteins?(Selectallthatapply.);Question9options;They are recognized by NKG2D receptors of NK cells and some CD8 T cells;TheyactivatetheNFBsignalingpathway;They activate mast cells in the intestinal wall;TheyarecloselyrelatedtoMHCclassIheavychains;TheybindtoMHCclassImoleculesandactivateCD8Tcells.;1and4arecorrect;2and4arecorrect;3and4arecorrect;If during development, none of the KIRs expressed by a NK cell are able to interact with self-MHC class;I molecules, then the NK cell retains expression of _____.;Question 10 options;LILRBI;KIR2DL1;KIR2DL2/3;KIR3DL1;CD94:NKG2A.;Question 11 (2.5 points);Which of the following are matched correctly? (Select all that apply.);Question 11 options;type I hypersensitivity: IgE;type II hypersensitivity: IgG;type III hypersensitivity: immune complexes;type IV hypersensitivity: delayed-type hypersensitivity;Allanswersarecorrect;Question 12 (2.5 points);An allergic reaction to poison ivy is associated with _____.;Question 12 options;mast-cell activation;an Arthus reaction;eosinophil activation;complement activation;cytotoxic T-cell activation.;Question 13 (2.5 points);Which of the following distinguishes IgE from the other antibody isotypes?;Question 13 options;IgE binds to Fc receptors on NK cells.;IgE binds to Fc receptors in the absence of antigen.;IgE is found in mucosal secretions.;IgE binds to matrix-associated antigens.;IgE stimulates receptor-mediated endocytosis by eosinophils.;Question 14 (2.5 points);Which of the following antigens must be compatible between a donor and a recipient of a blood;transfusion? (Select all that apply.);Question 14 options;ABO;Rh;HLA class I;HLA class II.;1and2;1,2and3;Allanswersarecorrect;Question 15 (2.5 points);is associated with a type III hypersensitivity reaction. (Select all that apply.);Question 15 options;allergen binding to cell-surface components and creating foreign epitopes;cross-linking of IgE on mast cells;formation of small immune complexes that are deposited in blood vessel walls;complement fixation;hemorrhaging;antibody excess.;1,2and3;3,4and5;Question 16 (2.5 points);An example of a live-attenuated virus vaccine is _____. (Select all that apply.);Question 16 options;Salk polio vaccine;measles vaccine;rabiesvaccine.;Allareliveattenuatedvirusvaccines;Question 17 (2.5 points);An example of an inactivated virus vaccine is _____. (Select all that apply.);Question 17 options;Sabin polio vaccine;mumpsvaccine;hepatitis B vaccine;rabies vaccine.;Allareinactivatedvirusvaccines.;Question 18 (2.5 points);Which of the following descriptions are true of Freunds complete adjuvant? (Select all that apply.);Question 18 options;It is made up of killed Bordetella pertussis and mineral oil.;Itismixedwithsolubleproteintoformaparticulateemulsion.;It enhances systemic dispersal of soluble protein antigens.;ItstimulatestheNFBpathwayinmacrophagesanddendriticcellsthroughactivatingNOD2.;1and4arecorrect;2and4arecorrect;Question 19 (2.5 points);A major attraction of immune stimulating complexes (ISCOMs) as an adjuvant is that they _____.;Question 19 options;form insoluble particles that resist dispersion and degradation;enhanceuptakebymacrophagesanddeliveryofantigentoendosomalcompartments;deliverantigentothecytosolforpresentationbyMHCclassI;bind to respiratory epithelium and mimic viral routes of entry;bind to Toll-like receptors and initiate a state of inflammation.;Question 20 (2.5 points);Alloantibodies to blood-vessel endothelium on solid organ grafts _____.;Question 20 options;are specific for HLA class I and class II antigens;cause hyperacute rejection;target endothelium for attack by NK cells;are IgA and do not fix complement;Question 21 (2.5 points);In general the higher the patients panel reactive antibody (PRA), _____.;Question 21 options;thehigherthenumberofsuitabletransplantdonors;thehighertheriskofdevelopingautoimmunity.;themorelimitedthenumberofsuitabletransplantdonors;PRAisusedtopredictParkinson'sdisease;Question 22 (2.5 points);Tacrolimus causes which of the following effects? (Select all that apply.);Question 22 options;reduced T-cell proliferation;decreasedproductionofIL3,IL4,GMCSF,andTNF;serumsickness.;1and2;1and3;Question 23 (2.5 points);For the patients new immune system to function effectively in bone marrow recipients, some HLA;allotypes must be shared because _____. (Select all that apply.);Question 23 options;professionalantigenpresentingcellsarehostderived;professionalantigenpresentingcellsaredonorderived;newlygeneratedTcellsarepositivelyselectedontherecipientsthymicepithelium;1and3;2and3;Question 24 (2.5 points);What is the probability that a sibling will be able to provide a HLA-haploidentical kidney for;transplantation?;Question 24 options;25%;50%;75%;100%;Question 25 (2.5 points);Tumor-specific antigens are derived from _____. (Select all that apply.);Question 25 options;peptide antigens encoded by fused portions of recombined genes;peptide antigens containing point mutations;proteinsmodifiedbyabnormalposttranslationalprocesses;viral proteins;non-contiguous peptides spliced together by peptide bonds in the proteasome.;Allanswersarecorrect;Question 26 (2.5 points);Which of the following describe types of tumor-associated antigens? (Select all that apply.);Question 26 options;Theyarederivedfromselfproteinstowhichtheimmunesystemisnottolerant.;TheyarederivedfromproteinsencodedbymRNAsthathaveundergoneabnormalposttranscriptionalspli;Theyareproteinsnormallyexpressedinimmunologicallyprivilegedsites.;1and3;2and3;Question 27 (2.5 points);A mechanism by which cancer cells can evade an immune response involves an alteration in the amount;of MIC on the cell surface by;Question 27 options;decreasingthelevelofMICtranscription;cleavageofMICatthecellsurfacebyaprotease;switchingfromatransmembraneformofMICtoasecretedform;cytosolic degradation of MIC in proteasomes;alternativemRNAsplicingresultinginatruncatedformofMICthatisnolongerableto;bindtoNKG2D.;Question 28 (2.5 points);Which of the following is a mechanism by which tumors can evade immune detection? (Select all that;apply.);Question 28 options;reductioninlevelsofHLAclassI;recruitmentofregulatoryTcells;loweringoflevelsofMIConcellsurface;Allanswersarecorrect;Question 29 (25 points);Monoclonal antibodies are used in cancer treatment because of their ability to _____. (Select all that;apply.);Question 29 options;target tumor cells for immune responses such as ADCC or opsonization;deliver radioactive molecules to track the status of metastasis;beconjugatedtocytotoxicdrugstokilltumorcells.

 

Paper#16035 | Written in 18-Jul-2015

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