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The Immune System, Peter Parham, 3rd Edition, Garland Publishing,

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need help with this exam. You match the terms with their definition. This class is immunology class, the text book we are using is The Immune System, Peter Parham, 3rd Edition, Garland Publishing;Attachment Preview;Exam 1.docx Download Attachment;ucleartranscriptionfactoractivatedbycytokineresponseto;produceinflammatorycytokines.;1.;Commens;ual;species;2.;Opportunistic;pathogens;3.;Defensins;4.;GALT;5.;C3b;6.;CD59;7.;MAC;8.;TLRs;9.;LPS;10. NFkappaB;11. LFA1:ICAM1;12. CRP;Save;Question3(20points);Matchgenes,terms,proteinsforchapters3and4.Youmayuseyournotecardsandmylecturenotesforthisquestion.;Onlyonechoicepermatch.;Question3options;Keygenesforsomaticrecombination,these;aretranscribedonlyinlymphocytes.;1.;Primary;Immune;Response;2.;SecondaryImmune;Response;Adaptiveresponsethatfollowsifpathogen;breachesskin,providesafirstexposureto;anantigenthisresponsetakessometime.;3.;ClonalSelection;4.;NegativeSelection;ProcessthatincreasesnumbersofBandT;cellsthatrecognizeaspecificpathogen;5.;CDR3;6.;Epitope;7.;SomaticRecombination;8.;RAG;ProcessofenhanceddiversificationofV;Domaincodingsequencesoccursafter;initialBcellactivation.;9.;PandNNucleotides;Processofcutting,splicingandrandom;recombinationthatproducesdiversityfor;antigenrecognition.;11. SomaticHypermutation;PalindromicandNontemplatedthese;nucleotidesfillinrandomlytocreatemore;diversityinCDR3;Adaptiveresponsethatfollowsifthe;antigenhasbeenpreviouslyseenthis;responseisfast.;Theshaperecognizedbyanantibody,this;isalsotheshapethatleadstotheMHC;presentationforTcellreceptors.;Keyfunctionofcertainantibodiesand;complementcomponentstocoatpathogens;andthusinactivatethem.;10. IsotypeSwitching;12. Opsins/Opsinization;StageinTCelldevelopmentwhereTcells;thatrecognizeselfaretargetedfor;Apoptosis.;Hypervariableloopkeyforrecognizing;antigens.;Processwhereantibodycanbemodified;(notantigenbindingregion)toproduce;alternativeeffectorfunctions.;Save;Question4(20points);Matchterms,genesandproteinsforchapters5and8.Onlyonechoicepermatch.Notecardsandmylecturenotesok!;Question4options;MasterProfessionalAntigenPresentingCell;(whiteglovesandall);Cellsurfacemoleculesfromprofessional;antigenpresentiingcellthatinteractwithT;cells.;ThisTcellreceptorbindstheB7ligand.;Lingand(relatedtoimmunoglobulinfamily);thatbindstheCD28coreceptor.;isfoundonantigenpresentingcellsand;indicatesapositiveinfection.;Thiscellsignalingmoleculetransducedthe;Tcellactivationinitiatedbyantigen;presentingbywayofphosphorylation.;Antigenprocessingcomponentsusedfor;MHC1presentation,Antigenprocessing;componentsusedforMHCIIpresentation.;NucleotidesequencesrecognizedbyRAG;genesforsomaticrecombination,Keygenes;onyexpressedinBandTcellsthatare;RSS,RAG1;and2;1.;2.;CD4,CD8;3.;MHCI,MHCII;4.;Proteasome,TAP;ERAP,Calnexin;Invariantchain,CLIP;5.;Allotype,Genetic;polymorphism;6.;MHCRestriction;7.;HLA1A,HLA1B,HLA;1C;8.;DendriticCell;9.;LFA1:ICAM2;CD2:LFA3;10. B7;thoughttohaveevolvedfromtransposons.;HLAisotypeswiththegreatestextentof;polymorphism.;Proteinsproducedbydifferentformsofa;givengene,Wheremuliplealternativeforms;ofageneexistinagivenpopulation.;CoreceptorforhelperTcells,Coreceptor;forcytotoxicTcells.;11. Zap70;12. CD28;Antigenpresentationthatindicates;intracellularpathogen,Antigenpresentation;thatindicatesextracellularpathogen.;WhereaTcellreceptorisspecifictoa;complexofboththeMHCandantigen;presentationforactivation.;Save;Question5(4points);PleaseseeFigure2.20(shownonslide11ofchapter2lecturenotes).ThisfigureshowstheTolllikereceptors.Theyare;highlightedontheopeningvideoforthischapter!WhichofthefollowingaretrueforthesekeycomponentsoftheInnate;Immunesystem?;Question5options;Thesereceptorsaresignalingmolecules.Thefamilymembersarespecificfor;differentmicrobes.Ourtextdescribesatleast9differentTLRsinthisfamilythat;providedetectionofspecificmicroorganisms.;Whenactivated,theseTLRswillactivatecellsignalingprocessesthatleadto;cytokineresponses.Forexample,whenLPSisrecognizedbyTLR4,akinase;cascaderesultsinthenuclearlocalizationofakeytranscriptionfactor(NFkappa;Beta)thatwillactivatethetranscriptionofinflammatorycytokines.;TollLikeReceptorsonlysensemicrobesontheoutersurfacesofcells.;1and2;2and3;Allanswersarecorrect;Save;Question6(4points);PleaseseeFigures3.8and3.9fromourtext.Theseareshownonslide8oftheChapter2lecture.Thesetwoclassesof;antigenpresentingmoleculesarecriticalforourwellbeingandthestarsofourDavisnovel.Infact,ourtextstatesthatMHC;genesare"thebestknownexamplesofhighlypolymorphicgenes".Whichofthefollowingstatementsaretrueforthesekey;molecules?;Question6options;MHCClassImoleculespresenttoCD8TcellsandinadditiontobindingtheTcell;receptor,thesebindtheCD8coreceptor.CD8TcellsarecytotoxicTcells.;MHCClassIImoleculespresenttoCD4TcellsandinadditiontobindingtheTcell;receptor,thesebindtheCD4coreceptor.CD4cellsarehelperTcells.;MHCClassImoleculespresentantigensfromintracellularpathogens(virusesfor;example)whileMHCClassIImoleculespresentantigensfromextracellular;pathogens(bacterial,viral,fungalandevenparasites).;MHCclassImoleculesareexpressedbyallcells(exceptforRedBloodCells)in;thebody,whileMHCclassIImoleculesareonlyexpressedondendriticcells;macrophagesandBcells.;1,2and3;Allanswersarecorrect.;Save;Question7(4points);Ourtextstatesthat"Thenumberofdifferentantibodiesthatcanbeproducedbythehumanbodyseemtobevirtually;limitless".Keytocreatingthediversitywitintheantigenbindingsites(Slide7ofchapter4lecture)aretheresultofrandom;recombinationofgenesegments.TheRAGgenesarekeyforcreatingthisprocess.PleaseseeSlide15fromthechapter4;lecturethatshowsFigures4.194.21.TheRAGstorylectureelaboratesonthesegenesandthisprocess.Pleaseselectthe;statementthatisNOTtrueaboutRAGGenesandrandomrecomination.;Question7options;SomaticrecombinationoccursduringBcelldevelopment.Duringthisprocess,the;V,DandJsegmentsarecutandsplicedandhelpproducethegreatvarietyof;antigenbindingsites.;VariableregionsequencesareflankedbyRSSs,thesesignalsequencesare;recognizedbytheRAGgenes.;JunctionaldiversityiscreatedbyexchangingVregionsforJregions.;JunctionaldiversityiscreatedbyhavingrandomNnucleotidesaddedafterRAG;genesclipRSSsgeneratingPnucleotides.;RAGgenesarethoughttohaveevolvedfromtransposons.;Save;Question8(4points);PleaseseeFigure5.20.Thisisshownonslide16ofthechapter5lecturenotes.Pleaseselectthestatement(s)that;correctlydescribethedifferencebetweenMHCclassIandMHCclassIIantigenprocessing.;Question8options;ThereisnodifferenceinhowantigenprocessingoccursforMHCclassIandMHC;classIImolecules.;AsMHCclassImoleculespresentantigensexclusivelyfromextracellular;pathogens,theextracellularantigensareengulfedandformanendocyticvesicle.;Peptidesarethenprocessedusingphagocytosis,andareboundbyMHC;molecules.;AsMHCclassIImoleculespresentantigensexclusivelyfromintracellular;pathogens,theintracellularantigensareprocessedinaproteasome.Peptidesare;thentransportedfromtheproteasomethroughTAPtotheERlumenwherethey;areloadedontotheMHCmolecule.;Answers2and3WOULDbecorrectiftheMHCclasstypewereswitched.;Specifically,answer3wouldbecorrectifMHCclassImoleculeswereidentified;andanswer2wouldbecorrectifMHCclassIImoleculeswereidentified.;Save;Question9(4points);Pleaseseethesummaryslideforourchapter8lecture.ThisslideshowsFigure8.39fromourtext.Pleaseselectthe;correctstatement(s)forthisquestiononthestagesoftheTcellresponse.;Question9options;NaiveTcellsmustbeactivatedinordertobecomeeffectorTcells.Specifically;NaiveCD8TcellsrecognizetheantigenpresentedbyMHCclassIImoleculesand;willthendevelopintohelperTcells.;NaiveTcellsmustbeactivatedinordertobecomeeffectorTcells.Specifically;NaiveCD8TcellsrecognizetheantigenpresentedbyMHCclassImoleculesand;willthendevelopintocytotoxicTcells.;CytotoxicTcellsrecognizecellsthathavebeeninfected(viral)andkillthemvia;Apoptosis.;HelperTcellsexistintwoforms,TH1cellsrecognizemacrophagesthatcontain;vesiclesofbacteriaandactivatethemacrophagestokillthebacteria,whileTH2;cellsactivateBcellsthatwilldevelopintoplamsacellsforantibodyproduction.;Answers1and3arecorrect;Answers2and3arecorrect;Save;Save All Responses

 

Paper#16257 | Written in 18-Jul-2015

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