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Cytopathic and non-cytopathic viruses elicit very different immune responses




Question 1;1.;Cytopathic and non-cytopathic viruses elicit very different immune responses. The primary;determining factor in the type of immune response to a viral infection is which of the following;(select one)?;Answer;A Initial inflammatory response to virus..;B. Whether virus is first recognized by macrophages;or dendritic cells;C. Genome;D.;type (RNA or DNA) of virus;Whether IgG or IgM antobodies are produced.;1 points;Question 2;1.;Many viruses evade the actions of NK cells by producing viral homologue of the host [x];receptor.;Answer;1 points;Question 3;1.;This phenomena occurs when memory T-cells specific for one virus are activated during infection by unrelated;virus.;Answer;A Systemic Inflammatory.;B. Superantigens;C. Antigen;Response Syndrome;Presentation;D Transcytosis.;E. Heterologous;T-cell Immunity;1 points;Question 4;1.;Match the following immune system cell types with their role in fighting a viral infection;Answer;Answer;Macrophages;ReadA Take up viral antigens in peripheral;Answer;Items. forissues present them to T-cells in;t;Question 4;the lymphoid organs;Dendritic;B. Cells that contain antigen specific;Cells;cell;Read Answer surface receptors and produce;s;Items for oluble antibodies specific for viral;Question ntigens;a4;C. Recognize and kill cells infected by;Helper T;cells viruses through recognition of;Read Answer;specific viral antigens on surface of;Items for;c4;Question ell;D Coordinate adaptive immune;Cytotoxic T.;Cells response by releasing cytokines;activation macrophages and;Read Answer;Items for timulating B-cells to produce;s;Question 4;antibody.;Natural;E. Scavenger phagocytic cells that are;Killer Cells;am;Read Answerajor source of inflammatory;c;Items for ytokines in innate immunity and;Question lso involved in antigen;a4;Plasmaresentation.;pB;Cells Kill virus infected cells by;F.;Read Answer;r;Items forecognizing the absence of MHC;on;Question 4 surface of infected cells.;3 points;Question 5;1.;Simple Overview of Immune response concept map;Answer;Answer;A Helper T-cell.;B. Cytotoxic T-cell;C. Macrophage;D Natural Killer Cell.;E. Dendritic Cell;F.;G.;H.;Plasma B-Cell;Naive B-Cell;Naive T-cell;4 points;Question 6;1.;Viruses are intracellular pathogens that can hide within a cell. The adaptive immune response responds to pathogens;using antibodies and T-cells, neither which are capable of entering cells and directly recognizing the virus. Briefy;describe how the adaptive immune response is able to recognize a cell is infected and eliminate infected cells (Max;5-6 sentences);Answer;PressTabtoenterthecontenteditor.Forthetoolbar,pressALT+F10(PC)orALT+FN+F10(Mac).;Path: p;Words:0;2 points;Question 7;1.;Which of the following are mechanims by which antibodies can inhibit a viral infection in;humans (Select all that apply)?;Answer;A Bind.;B. Bind;to viral polymerase and inhibit its ability to replicate viral genome;to virus antigen and recruit non-specific cells such as macrophages or NK cells to;engulf the virion or kill an infected cell.;C. Recognition of alpha(1,3) galactose which inhibits fusion of enveloped viruses in higher primates;D Bind.;E. Bind;to viral capsid or viral receptor and sterically prevent binding to host cell receptor;to T-cells and stimulate reelease of cytokines;2 points;Question 8;1.;The two picture below depict the pathways for antigen presentation to T-cells. Match the picture;with the the appropriate presentation pathway/T-cell type.;Answer;T-Cell A;Read Answer Items for;Question 8;T-Cell B;Read Answer Items for;Question 8;Answer;A MHC.;Class II Presentation to CD4+ T-Cell;(Helper T-Cell);B. MHC Class I Presentation CD8+ T-Cell;(Cytotoxic T-Cell);1 points;Question 9;1.;Which of the following mechanisms would enable a virus to evade the immune response (select;all that apply)?;Answer;A Virus downregulates expression of NK cell activating.;B. Enhance production of perforins by CD8+ T-cells;ligands;C. Activation;of NFkB transcription factor;Inhibit expression of MHC Class I molecules on surface of cell.;D.;E. Inhibition;of cellular proteasome pathways;2 points;Question 10;1.;A recent paper suggests that a mechanism by which the influenza virus can evade the adaptive;immune response is to kill influenza specific B-cells in the respiratory tract. Explain why this;might aid an influenza infection. In addition, given what you have learned about viruses and the;immune response, suggest a mechanism the virus could use to specifically kill B-cells (5-6;sentences max)..;Answer;PressTabtoenterthecontenteditor.Forthetoolbar,pressALT+F10(PC)orALT+FN+F10(Mac).;Path: p;Words:0;2 points;Question 11;1.;The figure below depicts antigen presentation to T-cells of two different strains of Dengue virus.;Explain why the difference in the viral antigen sequences alters the immune response to the;virus. How might viruses take advantage of this to evade the immune response (3-4 sentences;max)?;Answer;PressTabtoenterthecontenteditor.Forthetoolbar,pressALT+F10(PC)orALT+FN+F10(Mac).;Path: p;Words:0;2 points;Save and Submit;ClickSaveandSubmittosaveandsubmit.ClickSaveAllAnswerstosaveallanswers.


Paper#17607 | Written in 18-Jul-2015

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