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In problem 1, we had equal quantities of the 4 nucleotides

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In problem 1, we had equal quantities of the 4 nucleotides, so the random probability of identical;nucleotides in two aligned sequences is 0.25 (i.e., p = 0.25). Consider a DNA database in which;the ratio of A:C:G:T in the sequences is 0.35:0.15:0.15:0.35 (as would be the case for a genome;sequence from an organism has a 30% G+C content), and searching this database with a query;sequence with A:C:G:T equal to 0.15:0.35:0.35:0.15. If I take a random nucleotide from the;database, and a random nucleotide from the query sequence, what is the probability that they are;the same nucleotide? For full credit, you must describe your approach, or show enough;work to make clear how you solved the problem.

 

Paper#17986 | Written in 18-Jul-2015

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