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Which of the following are essential requirements for viral RNA synthesis for RNA viruses

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Question 1;1.;Which of the following are essential requirements for viral RNA synthesis for RNA viruses;(select all that apply)?;Answer;During replication RNA genome must be copied from one end to other without loss of;sequence;Viral RNAs are produced that can be translated by host ribosomes;May use host RNA polymerases for genome replication;RNA genome must be coated with nucleoprotein;mRNA synthesis must proceed through DNA intermediate;2 points;Question 2;1.;All RNA viruses require a primer to initiate RNA synthesis?;Answer;True;False;1 points;Question 3;1.;Which of the following classes of RNA viruses must contain the the translated viral polymerase within the mature;viral particle.;Answer;A (-) RNA Viruses.;B. ds RNA viruses;C. (+);D.;RNA Viruses;retroviruses;2 points;Question 4;1.;All RNA viruses replicate in the cytoplasm;Answer;True;False;2 points;Question 5;1.;The figure below depict two mechanisms of generating diversity in RNA viruses. A depicts Blank 1 while B;depicts Blank 2.;Answer;2 points;Question 6;1.;Match each retroviral enzyme with the step it catalyzes in the retroviral lifecycle.;Answer;A of;Formationnswer;A;RNA/DNAHost RNAse H.;duplex from;B. Viral RNAse H;ssRNA C.;Viral Integrase;genome D;Viral;Read Answer Items Reverse Transcriptase.;for Question 6;E. Host;Removal of;RNA from;RNA/DNA;duplex;Read Answer Items;RNA Polymerase II;for Question 6;Formation of;dsDNA from;ssDNA;complementary;to RNA;genome;Read Answer Items;for Question 6;Integration of;proviral DNA;into host;genome;Read Answer Items;for Question 6;Catalyzes;synthesis of;viral mRNA;from integrated;viral genome;Read Answer Items;for Question 6;2 points;Question 7;1.;This host protein is critical for selection of integration sites of HIV. Deletion of this protein;dramatically reduces the efficiency of integration;Answer;1 points;Question 8;1.;Segmented RNA viruses can do which of the following that other viruses cannot;Answer;A.;Mutation;B. RNA Editing;C. Reassortment;D.;Recombination;2 points;Question 9;1.;Most dsRNA viruses produce viral RNA within their capsids such that the viral genome;is only minimally exposed to the cytoplasm. In contrast, (+)ssRNA viruses remodel;cytoplasmic membranes to form viral RNA production factories. The red arrows in the;electron micrograph below show how the ssRNA Hepatitis C Virus dramatically;remodels the membranes of the endoplasmic reticulum to form a membraneous web;where viral RNA synthesis occurs. In 5-7 sentences, speculate why HCV forms these;membrane-bound replication complexes and what advantage they give the virus.;Answer;PressTabtoenterthecontenteditor.Forthetoolbar,pressALT+F10(PC)orALT+FN+F10(Mac).;Path: p;Words:0;2 points;Question 10;1.;The genome of a (+) RNA virus (not a retrovirus) acquires a mutation in the gene for the viral;polymerase. The polymerase produced from this mutated gene would be inactive. This single;copy of the genome is packaged in the virion and leaves the original host celll. Which of the;following statements are correct about this mutant virus (select all that apply)?;Answer;A A virus particle with the.;B. The mutant genome can;mutant genome can attach and enter a new host cell.;be translated in a new host cell;mutant genome would be copied to produce viral mRNA in the new host cell;The mutant virus can produce an exponential number of new viral progeny in the new host;cell.;C. The;D.;2 points;Question 11;1.;The genome of a (-) RNA virus acquires a mutation in the gene for the viral polymerase. The;polymerase produced from this mutated gene would be inactive. This single copy of the genome;is packaged normally in as a virion and leaves the original host celll. Which of the following;statements are correct about this mutant virus (select all that apply)?;Answer;A A virus particle with the.;B. The mutant genome can;mutant genome can attach and enter a new host cell.;be translated in a new host cell;C. The mutant genome would be copied to produce viral mRNA in the new host cell;D The mutant virus can produce an exponential number of new viral progeny in the new host.;cell.;View Full Attachment

 

Paper#18053 | Written in 18-Jul-2015

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