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Homework Assignment




Questions;1. You are interested in integrin activation and perform mutagenesis studies on;integrin. You find a mutant form of integrin which you call int-act, because the;int-act mutation causes the extracellular domain to exist always in an unfolded;state regardless of the presence or absence of ligand. When you determine the;sequence of int-act, you find that the mutation is in the intracellular domain of;integrin. Explain how this intracellular mutation could affect the conformation of;the extracellular domain of integrin.;2. Your friend, who is an engineering major, is interested in the mechanical;properties of extracellular matrix and wants to study how secreted collagen;molecules assemble into a collagen fiber. As part of his studies, he has been trying;to speed up the rate at which cells can produce the collagen protein and is;considering reducing the size of the propeptide that is attached to the collagen;chain such that it contains only the ER targeting sequence as well as the site for;cleavage of the propeptide. To his surprise, this modification causes collagen to;be degraded inside the cell. Can you explain why?


Paper#35453 | Written in 18-Jul-2015

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