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##### A clinical trial is conducted comparing a new pain medication for arthritis.

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**Question**

Question;1. A clinical trial is conducted comparing;a new pain medication for arthritis.;Participants are randomly assigned to receive the new medication or a;placebo. The outcome is pain relief;within 30 minutes. The data are shown;below.;Pain;Relief;No;Pain Relief;New Medication;44;76;Placebo;21;99;Estimate the;risk difference in pain relief between treatments;=;Estimate the;relative risk in pain relief between treatments;=;Estimate the;odds ratio in pain relief between treatments;=;The upper and;lower limits of the are shown below;Lower Limit of;CI: ____0.41;Upper Limit of;CI: ___1.61;Based on the Confidence Interval values which of the following are;true?;A.;One;can be 95% confident that the true value will be greater than the upper limit.;B.;One;can be 95% confident that the true value will be greater than the lower limit.;C. One can be 95% confident that the true;value will between the upper and lower limit.;D.;a;and b;2.The following data were collected in a clinical trial evaluating a;new compound designed to improve wound healing in trauma patients. The new compound is compared against a;placebo. After treatment for 5 days with;the new compound or placebo the extent of wound healing is measured and the;data are shown below.;Percent Wound Healing;Treatment;0-25%;26-50%;51-75%;76-100%;New Compound;(n=125);15;37;32;41;Placebo (n=125);36;45;34;10;Is there a;difference in the extent of wound healing by treatment? (Hint;Are treatment and the percent wound healing independent?) Run the appropriate test at a 5% level of;significance.;df=;alpha=;Reject H0;if?2>;Compute expected;frequencies;Expected Frequency = (Row Total *;Column Total)/N.;Complete the;expected frequencies for each cell.;Percent Wound Healing;Total;Treatment;0-25%;26-50%;51-75%;76-100%;New Compound;15;();37;();32;();41;();125;Placebo;36;();45;();34;();10;();125;Total;51;82;66;51;250;Compute?2.;?2=;Based on;comparing the computed?2to the rejection;level?2;which of the;following is (are) true?;A.;We;have statistically significant evidence at alpha=0.05 to show that H0;is false.;B.;Treatment;and percent wound healing are not independent.;C.;Treatment;and percent wound healing are independent.;D.;a;and b.;3. A clinical trial is conducted comparing;a new pain reliever for arthritis to a placebo.;Participants are randomly assigned to receive the new treatment or a;placebo and the outcome is pain relief within 30 minutes. The data are shown below.;Pain Relief;No Pain Relief;New Medication;44;76;Placebo;21;99;Is there a;significant difference in the proportions of patients reporting pain;relief? Run the test at a 5% level of;significance.;Reject H0 if Z;alpha=;=;=;=;Z =;Based on;comparing the computedzto the rejection levelzwhich of the following is (are) true?;A.;We;have statistically significant evidence at alpha=0.05 to show that H0;is false.;B.;We;have statistically significant evidence at alpha=0.05 to show thatthere a significant difference in the proportions of patients;reporting pain relief.;C.;We;do not have statistically significant evidence at alpha=0.05 to showthere a significant difference in the proportions of patients;reporting pain relief.;D.;a and b

Paper#62403 | Written in 18-Jul-2015

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